Effect of a single dose of methyl prednisolone as rescue medication for patients who develop hypotensive dengue shock syndrome during the febrile phase: a retrospective observational study

This is the authors' abstract. We don't add key points for this paper.

The dengue fever (DF) epidemic in 2009 in Sri Lanka resulted in nearly 370 deaths (1.4% case fatality), mainly adults.1 Although dengue shock syndrome (DSS) is thought to occur during the immediate afebrile phase of dengue infection, we encountered adult patients developing hypotensive DSS during the febrile phase. Although steroids have been shown to decrease cell infection rates and inhibit pro-inflammatory cytokines,2,3 existing data do not recommend routine use of steroids in the management of DF.