What question did this study set out to answer?

To investigate whether the proportion of isomeric trans fatty acids stored in adipose tissue is associated with the risk of acute myocardial infarction.

February 1, 1995Socio-Environmental Systems ModelingOpen Access

Adipose tissue isomeric trans fatty acids and risk of myocardial infarction in nine countries: the EURAMIC study

View Full Paper

Ask AI

Bookmark

Why the study?

Does a higher proportion of adipose tissue isomeric trans fatty acids increase the risk of acute myocardial infarction in men aged 70 years or less?

Population

1,388 men aged 70 years or less, comprising 671 with acute myocardial infarction and 717 controls without a…

Comparison

High levels of adipose tissue isomeric trans… vs Low levels of adipose tissue C18:1 trans fatty…

Design

Case-control

Authors

AAA. AroUniversidade de Rio Verde ISIrma SalminenFinnish Institute for Health and Welfare JHJussi K. HuttunenGeneral / Preventive / Lipids

Discussion

Member takes

Implication

No association seen between adipose C18:1 trans fatty acids and AMI; leaves open the contribution of trans fats to cardiovascular risk.

Key Points

To investigate whether the proportion of isomeric trans fatty acids stored in adipose tissue is associated with the risk of acute myocardial infarction.
Conducted an international multicenter case-control study (EURAMIC) in eight European countries and Israel with 671 men aged 70 years or younger with acute myocardial infarction (AMI) and 717 controls without a history of AMI.
Collected adipose tissue aspiration samples and measured fatty acid proportions, including 18-carbon isomeric trans monoenoic fatty acids (C18:1), using gas chromatography.
Mean (SD) proportion of adipose C18:1 trans fatty acids was 1.61 (0.92)% in AMI cases compared to 1.57 (0.86)% in controls.
The multivariate odds ratio for AMI comparing the highest to the lowest quartile of adipose C18:1 trans fatty acids was 0.97 (95% CI 0.56–1.67).
Excluding Spanish centers with very low trans fatty acid levels revealed a non-statistically significant trend toward increased AMI risk in the upper quartiles.

Structured PICO

Does a higher proportion of adipose tissue isomeric trans fatty acids increase the risk of acute myocardial infarction in men aged 70 years or less?

Population

1,388 men aged 70 years or less, comprising 671 with acute myocardial infarction (AMI) and 717 controls without a history of AMI, from eight European countries and Israel.

Intervention

High levels of adipose tissue isomeric trans monoenoic fatty acids (C18:1) (highest quartile)

Comparator

Low levels of adipose tissue C18:1 trans fatty acids (lowest quartile)

Outcome

Risk of acute myocardial infarction (AMI)hard clinical

Adipose tissue levels of C18:1 trans fatty acids were not significantly associated with an increased risk of acute myocardial infarction in this European and Israeli cohort.

Limitations

Cannot exclude the possibility that trans fatty acids have a significant impact on risk of AMI in populations with high intake

Cite This Study

Aro et al. (1995) studied this question.

synapsesocial.com/papers/6a7372d25db9ca0218c1e671 https://doi.org/10.1016/s0140-6736(95)90273-2

View Full Paper

Ask AI

Bookmark

Adipose tissue isomeric trans fatty acids and risk of myocardial infarction in nine countries: the EURAMIC study

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

Adipose tissue isomeric trans fatty acids and risk of myocardial infarction in nine countries: the EURAMIC study

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider