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February 13, 2010AJP Heart and Circulatory Physiology

Increased muscle sympathetic nerve activity acutely alters conduit artery shear rate patterns

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Why the study?

Do acute elevations in muscle sympathetic nerve activity alter conduit artery shear rate patterns in healthy men?

Population

14 healthy men, mean age 25 +/- 1 years

Comparison

Three sympathoexcitatory maneuvers: graded lower… vs Baseline measurements

Design

Other

Follow-up

acute

Authors

JPJaume PadillaVascular MedicineCYColin N. YoungGeorge Washington UniversityGSGrant H. SimmonsNike (United States)

Discussion

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Implication

Acute MSNA rises may increase retrograde/oscillatory shear in healthy men; hypothesis-generating, should not change practice.

Structured PICO

Do acute elevations in muscle sympathetic nerve activity alter conduit artery shear rate patterns in healthy men?

P
Population
14 healthy men, mean age 25 +/- 1 years
I
Intervention
Three sympathoexcitatory maneuvers: graded lower body negative pressure (LBNP) from 0 to -40 Torr, cold pressor test (CPT), and 35% maximal voluntary contraction handgrip followed by postexercise ischemia (PEI)
C
Comparator
Baseline measurements
O
Outcome
Conduit artery retrograde and oscillatory shear, muscle sympathetic nerve activity (MSNA), and arterial blood pressuresurrogate

Acute elevations in muscle sympathetic nerve activity are associated with increased conduit artery retrograde and oscillatory shear, which may be modulated by concurrent blood pressure changes.

Cite This Study

Padilla et al. (2010) studied this question.

synapsesocial.com/papers/6a7378f830bc69be694e5f12https://doi.org/10.1152/ajpheart.01133.2009
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Carotid baroreflex regulation of sympathetic nerve activity during dynamic exercise in humans2001 · 115 citations
  2. 2Brachial Artery Blood Flow Responses to Different Modalities of Lower Limb Exercise2009 · 201 citations
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  4. 4Hemodynamic Factors Changing Blood Flow Velocity Waveform and Profile in Normal Human Brachial Artery1985 · 21 citations
  5. 5Vascular Cell Adhesion Molecule-1 Expression in Endothelial Cells Exposed to Physiological Coronary Wall Shear Stresses2009 · 46 citations