February 1, 1974CirculationOpen Access

Antiarrhythmic Properties of Chlordiazepoxide

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Why the study?

Does chlordiazepoxide reduce ventricular arrhythmias in animal models of digitalis toxicity and coronary occlusion?

Structured PICO

Does chlordiazepoxide reduce ventricular arrhythmias in animal models of digitalis toxicity and coronary occlusion?

Population

Dial-urethane anesthetized cats with deslanoside-induced ventricular arrhythmias (n=12 intact, n=8 spinal-sectioned) and unanesthetized dogs 1 day after two-stage ligation of the anterior descending branch of the left coronary artery.

Intervention

Chlordiazepoxide (3.6-39.5 mg/kg i.v. in cats; 10 mg/kg i.v. in dogs), alone or as pretreatment to lidocaine.

Outcome

Conversion of ventricular arrhythmias to regular sinus rhythms (cats) and reduction in abnormal beats with increase in sinus beats (dogs).surrogate

Chlordiazepoxide demonstrates antiarrhythmic properties in animal models of digitalis toxicity and ischemia, likely mediated through central nervous system depression.

Discussion

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Implication

Hypothesis-generating for benzodiazepines in digitalis toxicity models; human trials required before any clinical consideration.

Cite This Study

Gills et al. (1974) studied this question.

synapsesocial.com/papers/6a737c905946a55bc0fb673f https://doi.org/10.1161/01.cir.49.2.272

View Full Paper

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Antiarrhythmic Properties of Chlordiazepoxide

Structured PICO

Discussion

Implication

Cite This Study

Antiarrhythmic Properties of Chlordiazepoxide

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider