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October 1, 1980BloodOpen Access

Serial studies in von Willebrand's disease: variability versus "variants"

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Why the study?

Does serial laboratory testing reveal variability in diagnostic markers in patients with von Willebrand's disease?

Population

50 individuals from 25 families with von Willebrand's disease (vWd), and 10 normal individuals

Comparison

Serial laboratory testing of bleeding time… vs Normal individuals (n=10)

Design

Cohort

Authors

CAC F AbildgaardGalecto (Denmark)ZSZ SuzukiScripps HealthJHJ HarrisonScripps Health

Discussion

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Implication

Supports serial testing for vWD diagnosis; leaves open optimal intervals and thresholds.

Structured PICO

Does serial laboratory testing reveal variability in diagnostic markers in patients with von Willebrand's disease?

P
Population
50 individuals from 25 families with von Willebrand's disease (vWd), and 10 normal individuals
I
Intervention
Serial laboratory testing of bleeding time (BT), factor VIII coagulant activity (VIII:C), factor-VIII-related antigen (VIIIR:Ag), and ristocetin cofactor (VIIIR:Rcof)
C
Comparator
Normal individuals (n=10)
O
Outcome
Variability of laboratory findings over timesurrogate

Serial testing demonstrates significant intra-individual variability in von Willebrand's disease laboratory markers, suggesting that single-timepoint testing is insufficient for diagnosis or variant classification.

Cite This Study

Abildgaard et al. (1980) studied this question.

synapsesocial.com/papers/6a7381e1d3d4e530dbfb6859https://doi.org/10.1182/blood.v56.4.712.712
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Heightened Interaction between Platelets and Factor VIII/von Willebrand Factor in a New Subtype of von Willebrand's Disease1980 · 374 citations
  2. 2Quantitative Assay of a Plasma Factor Deficient in von Willebrand's Disease that is Necessary for Platelet Aggregation. RELATIONSHIP TO FACTOR VIII PROCOAGULANT ACTIVITY AND ANTIGEN CONTENT1973 · 425 citations
  3. 3The Factor VIII Abnormality in Severe von Willebrand's Disease1979 · 50 citations
  4. 4VASCULAR HEMOPHILIA1956 · 66 citations
  5. 5Clues to the Pathogenesis of Bleeding in von Willebrand's Disease1973 · 49 citations