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October 1, 2002Diabetes CareOpen Access

Predicting Future Cardiovascular Disease

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Why the study?

Do multivariate clinical models predict incident cardiovascular disease better than oral glucose tolerance tests in adults without known diabetes or CVD?

Population

4,257 adults, 25-64 years of age, free of both cardiovascular disease and known diabetes at baseline, from…

Comparison

Multivariate models incorporating commonly… vs Oral glucose tolerance tests / 2-h plasma glucose

Design

Cohort

Follow-up

7-8 years

Authors

MSMichael P. SternThe University of Texas Health Science Center at San AntonioPFPedram FatehiStanford UniversityKWKen WilliamsUniversity of Technology Sydney

Discussion

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Implication

Standard clinical variables may outperform glucose testing for CVD prediction in nondiabetics; hypothesis-generating for updated risk models pending validation.

Structured PICO

Do multivariate clinical models predict incident cardiovascular disease better than oral glucose tolerance tests in adults without known diabetes or CVD?

P
Population
4,257 adults (2,662 Mexican-Americans and 1,595 non-Hispanic whites), 25-64 years of age, free of both cardiovascular disease (CVD) and known diabetes at baseline, from San Antonio census tracts.
I
Intervention
Multivariate models incorporating commonly available clinical variables (medical history, cigarette smoking history, BMI, blood pressure, fasting glucose, fasting insulin, triglycerides, and fasting total, LDL, and HDL cholesterol)
C
Comparator
Oral glucose tolerance tests (OGTTs) / 2-h plasma glucose
O
Outcome
Incident cardiovascular disease (CVD) at 7-8 years of follow-uphard clinical

Standard clinical variables predict future cardiovascular disease better than oral glucose tolerance tests in individuals without known diabetes.

Cite This Study

Stern et al. (2002) studied this question.

synapsesocial.com/papers/6a73881130bc69be694e6522https://doi.org/10.2337/diacare.25.10.1851

Topics

Women and heart diseaseGLP-1 agonists cardiovascular outcomes
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Also Consider

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  1. 1Effects of Diabetes and Level of Glycemia on All-Cause and Cardiovascular Mortality: The San Antonio Heart Study1998 · 479 citations
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