Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 1, 2015Blood Pressure

Effects of dapagliflozin on blood pressure in hypertensive diabetic patients on renin–angiotensin system blockade

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does dapagliflozin reduce systolic blood pressure and HbA1c in patients with inadequately controlled T2DM and hypertension on renin-angiotensin system blockade?

Population

613 patients with inadequately controlled type 2 diabetes mellitus and hypertension, despite ongoing therapy…

Comparison

Dapagliflozin 10 mg once daily for 12 weeks. vs Placebo once daily for 12 weeks.

Design

RCT, randomized, double-blind

Follow-up

12 weeks

Authors

MWMichael A. WeberTMTraci A. MansfieldFAFederica Alessi

Discussion

Loading...

Member takes

Overview

Dapagliflozin offers dual BP and glycemic benefit atop RAS blockade in T2DM; extends SGLT2 inhibitor evidence to hypertensive patients.

Structured PICO

Does dapagliflozin reduce systolic blood pressure and HbA1c in patients with inadequately controlled T2DM and hypertension on renin-angiotensin system blockade?

P
Population
613 patients with inadequately controlled type 2 diabetes mellitus (T2DM) and hypertension, despite ongoing therapy with a renin-angiotensin system blocker.
I
Intervention
Dapagliflozin 10 mg once daily for 12 weeks.
C
Comparator
Placebo once daily for 12 weeks.
O
Outcome
Change from baseline to week 12 in seated systolic blood pressure (SBP) and glycosylated hemoglobin (HbA1c).surrogate

Dapagliflozin provides additional blood pressure and glycemic lowering benefits in patients with T2DM and hypertension already treated with RAS blockers.

Cite This Study

Weber et al. (2015) studied this question.

synapsesocial.com/papers/6a7388358317ef39e84e6407https://doi.org/10.3109/08037051.2015.1116258
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Antihypertensive effect of Dapagliflozin in Type II diabetic patients with Hypertension2024 · 1 citations
  2. 2Dapagliflozin lowers blood pressure in hypertensive and non-hypertensive patients with type 2 diabetes2015 · 98 citations
  3. 3Long-term study of patients with type 2 diabetes and moderate renal impairment shows that dapagliflozin reduces weight and blood pressure but does not improve glycemic control2013 · 651 citations
  4. 4Dapagliflozin and blood pressure control in type 2 diabetes: a meta-analysis of randomised clinical trials2025
  5. 5Dapagliflozin and Blood Pressure in Patients with Chronic Kidney Disease and Albuminuria2024 · 17 citations