What question did this study set out to answer?

To examine the association between fasting serum C-peptide, a biomarker of insulin secretion measured three years post-diagnosis, and all-cause and breast cancer-specific mortality.

November 30, 2010Journal of Clinical OncologyOpen Access

Fasting C-Peptide Levels and Death Resulting From All Causes and Breast Cancer: The Health, Eating, Activity, and Lifestyle Study

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Authors

MIMelinda L. IrwinYale Cancer Center CDCatherine DugganCape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa CWChing-Yun WangUniversity of Washington

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Implication

Prospective observational study reveals elevated fasting C-peptide levels increase mortality risk in breast cancer survivors, suggesting insulin reduction strategies could improve survival.

Key Points

To examine the association between fasting serum C-peptide, a biomarker of insulin secretion measured three years post-diagnosis, and all-cause and breast cancer-specific mortality.
Prospective observational study of 604 women diagnosed with local or regional breast cancer between 1995 and 1998 in the HEAL Study, followed until death or December 31, 2006.
Multivariable stratified Cox regression analyses were performed to calculate hazard ratios (HR) and 95% confidence intervals for mortality according to C-peptide levels.
In women without type 2 diabetes, each 1-ng/mL increase in fasting C-peptide was associated with an increased risk of all-cause mortality (HR = 1.31; 95% CI, 1.06 to 1.63; P = .013) and breast cancer death (HR = 1.35; 95% CI, 1.02 to 1.87; P = .048).
Associations between C-peptide levels and breast cancer death were stronger in women with type 2 diabetes, body mass index < 25 kg/m², higher disease stage, and estrogen receptor-positive tumors.

Cite This Study

Irwin et al. (2010) studied this question.

synapsesocial.com/papers/6a7393d8932cfe51ab71b47e https://doi.org/10.1200/jco.2010.28.4752

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Implication

Prospective observational study reveals elevated fasting C-peptide levels increase mortality risk in breast cancer survivors, suggesting insulin reduction strategies could improve survival.

Fasting C-Peptide Levels and Death Resulting From All Causes and Breast Cancer: The Health, Eating, Activity, and Lifestyle Study

Discussion

Member takes

Implication

Key Points

Cite This Study

Fasting C-Peptide Levels and Death Resulting From All Causes and Breast Cancer: The Health, Eating, Activity, and Lifestyle Study

Discussion

Member takes

Implication

Key Points

Cite This Study

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