August 15, 2001Cardiovascular Research

Differential expression of cardiac ANP and BNP in a rabbit model of progressive left ventricular dysfunction

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Population

16 rabbits

Comparison

Progressive rapid ventricular pacing vs Unpaced control group

Design

Preclinical

Follow-up

up to 30 days

Authors

ALAndreas LuchnerKrankenhaus Barmherzige Brüder

Discussion

Member takes

Implication

LV-BNP upregulation in experimental CHF supports BNP as LV marker; animal data leaves open human translation.

Structured PICO

Population

16 rabbits (6 subjected to progressive pacing to congestive heart failure, 5 subjected to pacing to early LV dysfunction, 5 controls)

Intervention

Progressive rapid ventricular pacing (330 to 380 bpm over 30 days for CHF; 330 bpm for 10 days for early LV dysfunction)

Comparator

Unpaced control group

Outcome

ANP and BNP gene expression in atrial and left ventricular tissuesurrogate

The differential activation of ANP and BNP during the progression to heart failure provides a molecular basis for BNP as a superior marker of LV dysfunction.

Cite This Study

Andreas Luchner (2001) studied this question.

synapsesocial.com/papers/6a73967b1aa2fc9e78fb6af2 https://doi.org/10.1016/s0008-6363(01)00316-9

Topics

Heart failure HFrEF treatment

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Differential expression of cardiac ANP and BNP in a rabbit model of progressive left ventricular dysfunction

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Differential expression of cardiac ANP and BNP in a rabbit model of progressive left ventricular dysfunction

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider