Nonmuscle myosin II localizes to the Z-lines and intercalated discs of cardiac muscle and to the Z-lines of skeletal muscle

View Full Paper

Ask AI

Bookmark

Population

Normal human and mouse hearts and human skeletal muscles (fresh-frozen sections)

Design

Preclinical

Authors

Discussion

May indicate contractile roles in cardiac myocytes; leaves open isoform-specific functions in human sarcomere dynamics.

Population

Normal human and mouse hearts and human skeletal muscles (fresh-frozen sections)

Intervention

Immunohistochemical staining using polyclonal antibodies against nonmuscle myosin heavy chain II-A (NMHC II-A) and II-B (NMHC II-B)

Outcome

Localization of NMHC II-A and NMHC II-B proteinssurrogate

The presence of nonmuscle myosin II in Z-lines and intercalated discs suggests a dynamic role in muscle contraction and relaxation mechanisms.

Takeda et al. (2000) studied this question.

View Full Paper

Ask AI

Bookmark