Why the study?
Does natural human IFN-alpha require dosage modifications in hemodialysis patients?
Population
15 hemodialysis patients and 1 nonhemodialysis patient with poor renal function
Comparison
Natural human interferon-alpha 5 million IU… vs Subjects with normal renal function
Design
Other
Follow-up
5 days
Authors
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Supports no dosage adjustment for natural human IFN-alpha in hemodialysis; extends limited PK data but leaves open need for prospective validation.
Does natural human IFN-alpha require dosage modifications in hemodialysis patients?
Dosage modifications of natural human IFN-alpha are unnecessary for patients with low renal function, including those undergoing hemodialysis.
Gotoh et al. (1999) studied this question.
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