Why the study?
Does amlodipine improve left ventricular diastolic and long axis functions compared to lacidipine in hypertensive patients with stable angina and isolated diastolic dysfunction?
Population
59 hypertensive patients with associated coronary artery disease and isolated diastolic dysfunction
Comparison
Amlodipine for 4 weeks vs Lacidipine for 4 weeks
Design
RCT, randomized
Follow-up
4 weeks
Authors
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Amlodipine improves LV diastolic parameters where lacidipine does not in hypertensive angina; extends comparative CCB data on relaxation in isolated diastolic dysfunction.
Does amlodipine improve left ventricular diastolic and long axis functions compared to lacidipine in hypertensive patients with stable angina and isolated diastolic dysfunction?
Amlodipine, but not lacidipine, improves echocardiographic markers of left ventricular diastolic and long axis function in patients with hypertension and stable angina.
Žaliūnas et al. (2005) studied this question.
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