Why the study?
Does chronic therapy with verapamil and nicardipine improve left ventricular diastolic function in patients with stable angina?
Population
Patients with stable angina
Comparison
Chronic therapy with verapamil and nicardipine vs Placebo (crossover design)
Design
RCT, Randomized crossover, Double-blind
Authors
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Supports calcium antagonists for diastolic improvement in stable angina; extends evidence to objective filling indices with chronic therapy.
Does chronic therapy with verapamil and nicardipine improve left ventricular diastolic function in patients with stable angina?
Chronic treatment with calcium antagonists (verapamil and nicardipine) partially corrects left ventricular relaxation abnormalities in patients with stable angina.
Rodrigues et al. (1987) studied this question.
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