Why the study?
Does nicardipine compared to verapamil improve blood pressure and left ventricular function in patients with essential hypertension?
Population
30 patients with essential hypertension
Comparison
Nicardipine 30 mg three times daily for 6 weeks vs Verapamil 160 mg twice daily for 6 weeks
Design
Other
Follow-up
6 weeks per treatment period
Authors
Loading...
May favor nicardipine in hypertensive patients with reduced cardiac function; leaves open differential LV effects in larger trials.
Does nicardipine compared to verapamil improve blood pressure and left ventricular function in patients with essential hypertension?
Nicardipine and verapamil provide similar blood pressure reduction, but nicardipine may be safer for patients with compromised cardiac function due to its lack of heart rate depression and improvement in left ventricular shortening.
Al-Khawaja et al. (1986) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: