What question did this study set out to answer?

This study aims to evaluate the effects of chronic calcium antagonist therapy on left ventricular function in patients with ischemic heart disease.

December 1, 1986British Journal of Clinical PharmacologyOpen Access

Calcium antagonist treatment and its effects on left ventricular function in patients with ischaemic heart disease

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Why the study?

Does chronic therapy with nicardipine and verapamil improve left ventricular function in patients with chronic stable angina?

Population

n=21 patients with chronic stable angina

Comparison

Chronic therapy with nicardipine and verapamil… vs Placebo and active cross-over comparison

Design

RCT, double-blind

Follow-up

4 weeks per treatment period

Authors

ERE.A. RodriguesNorthwick Park Hospital IAImad Al-KhawajaNorthwick Park Hospital ALAvijit LahiriCardiac Imaging

Discussion

Member takes

Implication

Supports calcium antagonist use for exercise capacity in stable angina; extends evidence favoring nicardipine over verapamil for exercise left ventricular systolic function.

Key Points

This study aims to evaluate the effects of chronic calcium antagonist therapy on left ventricular function in patients with ischemic heart disease.
Double-blind, cross-over protocol
21 patients with chronic stable angina
Radionuclide angiography before and after each 4-week treatment with nicardipine and verapamil.
Heart rates were significantly lower on verapamil than nicardipine.
Ejection rate was significantly higher on nicardipine during exercise, indicating improved function.
Resting ejection rate index was greater on verapamil compared to nicardipine.

Structured PICO

Does chronic therapy with nicardipine and verapamil improve left ventricular function in patients with chronic stable angina?

Population

n=21 patients with chronic stable angina

Intervention

Chronic therapy with nicardipine and verapamil for 4 weeks each

Comparator

Placebo and active cross-over comparison

Outcome

Left ventricular function assessed by rest and exercise radionuclide angiographysurrogate

Nicardipine may offer improved exercise systolic left ventricular function compared to verapamil in patients with chronic stable angina.

Cite This Study

Rodrigues et al. (1986) studied this question.

synapsesocial.com/papers/6a703a3122b3175134db4db5 https://doi.org/10.1111/j.1365-2125.1986.tb00339.x

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Implication

Supports calcium antagonist use for exercise capacity in stable angina; extends evidence favoring nicardipine over verapamil for exercise left ventricular systolic function.

Calcium antagonist treatment and its effects on left ventricular function in patients with ischaemic heart disease

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Calcium antagonist treatment and its effects on left ventricular function in patients with ischaemic heart disease

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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