What question did this study set out to answer?

To determine the developmental role of the homeobox-containing gene tinman in mesodermal patterning and heart formation.

July 1, 1993Development

The gene tinman is required for specification of the heart and visceral muscles in Drosophila

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Authors

RBRolf BodmerPediatric / Congenital Cardiology

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Implication

Genetic study demonstrates that tinman is essential for heart and visceral mesoderm development in Drosophila embryos, indicating a critical early role in mesoderm subdivision.

Key Points

To determine the developmental role of the homeobox-containing gene tinman in mesodermal patterning and heart formation.
Examined embryonic mesodermal patterning and organ specification in Drosophila embryos carrying loss-of-function mutations in tinman.
Assayed phenotypic rescue by driving ubiquitous tinman cDNA expression under control of a heat-shock promoter in mutant embryos.
tinman mutant embryos showed complete absence of visceral mesoderm and heart primordia, alongside impaired fusion of the anterior and posterior endoderm.
Somatic body wall muscles formed abnormally in mutants despite the loss of cardiac and visceral musculature.
Heat-shock-driven expression of tinman cDNA partially restored the formation of both heart cells and visceral mesoderm.

Cite This Study

Rolf Bodmer (1993) studied this question.

synapsesocial.com/papers/6a73a36d9e855e455c279eba https://doi.org/10.1242/dev.118.3.719

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Implication

Genetic study demonstrates that tinman is essential for heart and visceral mesoderm development in Drosophila embryos, indicating a critical early role in mesoderm subdivision.

The gene tinman is required for specification of the heart and visceral muscles in Drosophila

Discussion

Member takes

Implication

Key Points

Cite This Study

The gene tinman is required for specification of the heart and visceral muscles in Drosophila

Discussion

Member takes

Implication

Key Points

Cite This Study

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