September 2, 2015JAMA DermatologyOpen Access

A Novel Chromosomal Translocation Associated WithCOL1A2-PDGFBGene Fusion in Dermatofibrosarcoma Protuberans

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Population

78 patients from pathologic databases of the University of the Ryukyus and Gunma University.

Design

Cohort

Authors

INIkumi NakamuraNagasaki University YKYoshiyuki KariyaUniversity of the Ryukyus University Hospital EOEtsuko OkadaNational Hospital Organization Takasaki Medical Center

Discussion

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Implication

PDGFB expression may support DFSP diagnosis; leaves open whether alternative fusions drive fusion-negative cases.

Structured PICO

Population

78 patients (30 with Dermatofibrosarcoma protuberans [DFSP] tumors and 48 with non-DFSP mesenchymal tumors) from pathologic databases of the University of the Ryukyus and Gunma University.

Intervention

Immunohistochemical analysis of PDGFB and other markers, and genetic analysis for fusion genes (COL1A1-PDGFB and others).

Outcome

Presence of the COL1A1-PDGFB fusion gene and expression of PDGFB in DFSP tumors.surrogate

PDGFB protein is expressed in most DFSP tumors and a novel COL1A2-PDGFB fusion gene exists, supporting the concept that DFSP is a PDGFB-dependent tumor.

Cite This Study

Nakamura et al. (2015) studied this question.

synapsesocial.com/papers/6a73a371ce5bb8565d4c9f0e https://doi.org/10.1001/jamadermatol.2015.2389

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A Novel Chromosomal Translocation Associated WithCOL1A2-PDGFBGene Fusion in Dermatofibrosarcoma Protuberans

Discussion

Member takes

Implication

Structured PICO

Cite This Study

A Novel Chromosomal Translocation Associated WithCOL1A2-PDGFBGene Fusion in Dermatofibrosarcoma Protuberans

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider