Key result
Real-time PCR detected COL1A1-PDGFB fusion transcripts in 7 of 8 cases of dermatofibrosarcoma protuberans containing sarcoma, including 3 cases with pleomorphic sarcoma.
Population
8 cases of dermatofibrosarcoma protuberans (DFSP) containing sarcoma (DFSP-FS and DFSP-PleoSarc)
Design
Case_series
Authors
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May aid sarcomatous DFSP diagnosis; leaves open histogenetic confirmation pending larger studies.
Observational (n=8)
Real-time PCR can detect COL1A1-PDGFB fusion transcripts in sarcomatous DFSP, aiding in diagnosis and supporting a common histogenesis.
Szöllősi et al. (2006) conducted an observational in Dermatofibrosarcoma protuberans containing sarcoma (n=8). Real-time polymerase chain reaction assay for COL1A1-PDGFB fusion transcript was evaluated on Detection of COL1A1-PDGFB fusion transcript. Real-time PCR detected COL1A1-PDGFB fusion transcripts in 7 of 8 cases of dermatofibrosarcoma protuberans containing sarcoma, including 3 cases with pleomorphic sarcoma.