June 1, 2009HistopathologyOpen Access

Dermatofibrosarcoma protuberans: clinical, pathological, and genetic (COL1A1‐PDGFB ) study with therapeutic implications

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Population

20 patients with dermatofibrosarcoma protuberans (DFSP), including 14 men and 6 women.

Design

Case_series

Authors

BLB. LlombartFundación Instituto Valenciano de Oncología OSOnofre SanmartínFundación Instituto Valenciano de Oncología JLJosé Antonio López‐GuerreroConsejo Superior de Investigaciones Científicas

Discussion

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Implication

Supports COL1A1-PDGFB testing in DFSP; hypothesis-generating for breakpoint effects on outcomes.

Structured PICO

Population

20 patients with dermatofibrosarcoma protuberans (DFSP), including 14 men and 6 women.

Intervention

Analysis of COL1A1-PDGFB transcripts using multiplex reverse transcriptase-polymerase chain reaction; treatment with Mohs surgery (n=19) or imatinib (n=2).

Outcome

Presence of COL1A1-PDGFB transcripts and relationship between COL1A1 breakpoints and clinical and histopathological variables.surrogate

The COL1A1-PDGFB fusion is present in most DFSP cases across histological subtypes, though breakpoints do not correlate with clinicopathological parameters.

Cite This Study

Llombart et al. (2009) studied this question.

synapsesocial.com/papers/6a7d4cd6c7e6f6a50737d395 https://doi.org/10.1111/j.1365-2559.2009.03310.x

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Dermatofibrosarcoma protuberans: clinical, pathological, and genetic (COL1A1‐PDGFB ) study with therapeutic implications

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Dermatofibrosarcoma protuberans: clinical, pathological, and genetic (COL1A1‐PDGFB ) study with therapeutic implications

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider