A novel double crosslinking strategy for decellularized bovine pericardium improves anti-calcification, mechanical, and biocompatibility properties, offering a promising alternative to glutaraldehyde fixation for bioprosthetic heart valves.
Should not yet alter BHV fixation practice; leaves open clinical translation of this anti-calcification strategy.
results revealed that P(APM/MPC)-OCS-BP exhibited an excellent anti-calcification property. In a word, this simple cooperative crosslinking strategy provides a novel solution to obtain BHVs with good mechanical properties, and HUVEC-cytocompatibility, anti-coagulation, anti-inflammatory and anti-calcification properties. It might be a promising alternative to GA-fixed BP and exhibited good prospects in clinical applications.
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Shi et al. (2024) studied this question.
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