Why the study?
The effects of prolonged hypobaric hypoxia on cardiac baroreflex sensitivity and the underlying mechanisms in young women were not well understood.
Does prolonged hypobaric hypoxia affect cardiac baroreflex sensitivity in young women?
Does prolonged hypobaric hypoxia affect cardiac baroreflex sensitivity in young women?
Prolonged hypobaric hypoxia reduces cardiac baroreflex sensitivity in young women, an effect mediated by arterial chemoreflex mechanisms rather than pulmonary ventilation.
Potential baroreflex impairment at altitude merits caution in women; leaves open chemoreflex mediation for confirmatory studies.
We examined the effects of prolonged hypobaric hypoxia (corresponding to ∼3,500-m altitude) on cardiac baroreflex sensitivity (cBRS) in young women and investigated underlying mechanisms. We found that cBRS was reduced in hypoxia and that this reduction was attenuated by acute restoration of inspiratory oxygen partial pressure but not by volitional restraint of pulmonary ventilation. These findings help to elucidate the role of arterial chemoreflex mechanisms in the control of cBRS during hypobaric hypoxia in young women.
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Fisher et al. (2022) studied this question.
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