January 1, 2010Annals of Medicine

B-type natriuretic peptide as a predictor of declining cognitive function and dementia—a cohort study of an elderly general population with a 5-year follow-up

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Why the study?

Does elevated B-type natriuretic peptide (BNP) predict cognitive decline and dementia in an elderly general population?

Population

464 subjects free of dementia aged 75 years or more from an elderly general population

Comparison

Elevated B-type natriuretic peptide (BNP) vs Lower B-type natriuretic peptide or previously…

Design

Cohort

Follow-up

5 years

Authors

TKTuomas KerolaElectrophysiology TNTuomo NieminenElectrophysiology SHSirpa HartikainenUniversity of Eastern Finland

Discussion

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Implication

Elevated BNP should not yet change dementia risk assessment in the elderly; hypothesis-generating and requires prospective validation.

Structured PICO

Does elevated B-type natriuretic peptide (BNP) predict cognitive decline and dementia in an elderly general population?

Population

464 subjects free of dementia aged 75 years or more from an elderly general population

Intervention

Elevated B-type natriuretic peptide (BNP)

Comparator

Lower B-type natriuretic peptide (BNP) or previously known risk markers

Outcome

Decline of Mini Mental State Examination (MMSE) score and onset of dementia during a 5-year follow-uphard clinical

Elevated BNP is an independent predictor of cognitive decline and incident dementia in the elderly, suggesting a potential link between cardiovascular stress and cognitive impairment.

Cite This Study

Kerola et al. (2010) studied this question.

synapsesocial.com/papers/6a73aec8aa90adf506fb7447 https://doi.org/10.3109/07853891003652542

Topics

Hypertension management

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B-type natriuretic peptide as a predictor of declining cognitive function and dementia—a cohort study of an elderly general population with a 5-year follow-up

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

B-type natriuretic peptide as a predictor of declining cognitive function and dementia—a cohort study of an elderly general population with a 5-year follow-up

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider