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July 1, 1992The Journal of ImmunologyOpen Access

Presentation of three different viral peptides, HTLV-1 Tax, HCMV gB, and influenza virus M1, is determined by common structural features of the HLA-A2.1 molecule

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Population

HLA-A2.1 molecule and a panel of 11 HLA-A2 mutants with single amino acid substitutions within pockets…

Design

Preclinical

Authors

UUUrsula UtzNational Institutes of HealthSKSara C. KoenigBoston UniversityJCJ E ColiganUniversity of Alabama at Birmingham

Discussion

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Implication

Reveals shared HLA-A2 structural features for diverse viral peptides; leaves open translation to human immunity or therapies.

Structured PICO

P
Population
HLA-A2.1 molecule and a panel of 11 HLA-A2 mutants with single amino acid substitutions within pockets present in the peptide binding site
I
Intervention
Presentation of three different viral peptides: HTLV-I Tax peptide 12-19, HCMV gB 619-628, and influenza M1 58-66
O
Outcome
Influence of different pockets of the HLA-A2.1 molecule on the presentation of the viral peptides

Common structural features in HLA-A2 determine the binding of different structurally diverse viral peptides.

Cite This Study

Utz et al. (1992) studied this question.

synapsesocial.com/papers/6a73b18ddce227fde44ca1dehttps://doi.org/10.4049/jimmunol.149.1.214
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