Role Of Insulin Like Growth Factor-1 and Insulin Like Growth Factor Binding Protein-3 In Patients Of Coronary Artery Disease Attending Suez Canal University Hospital

Cardiovascular disease is the leading cause of mortality, not only in the Westernworld, but also in developing countries. It has been suggested that circulating insulinlike growth factor-1 (IGF-I) and insulin like growth factor binding protein-3(IGFBP-3) are involved in the pathophysiological processes underlying coronary arterydisease. We evaluated the relationship between the levels of IGF-I and IGFBP-3 ndcoronary atherosclerosis in sixty two patients attending Cardiac Clinic and CoronaryCare Unit at Suez Canal University Hospital, and 30 healthy controls. IGF-1 andIGFBP-3 were measured using Immulite 1000. Fasting blood glucose and lipidprofile were measured for all subjects. Coronary artery disease was more frequentamong males compared to females (67.7%, and 32.3% respectively). Total cholesterol(TC), low density lipoprotein cholesterol (LDLc) and triacylglycerol (TAG) levelswere significantly higher, while HDL was significantly lower in patients thancontrols. The means of IGF-1 and IGFBP-3 were significantly higher among controlgroup compared to patients group (212.5 ± 109.1 ng/ml and 6.4 ± 2.3 ng/ml versus129.5 ± 66.2 ng/ml., 4.4 ± 1.6 ng/ml respectively, p= 0.001 for each). Thirty (48.4%)of patients had 3 stenosed vessels. The mean percent of stenosis was 74.7 ± 14.2 %.IGF-1 and IGFBP-3 were lower in the group of three affected vessels but there wasno significant correlation between both parameters and severity of the disease. Therewas significant correlation between IGF-1 and HDL (r =0.254, p-value = 0.046) inpatients group while no significant correlation between IGF-1 and other parametersin both groups. There was no significant correlation between IGFBP-3 and otherparameters in both groups. In conclusion, IGF-1, IGFBP-3 may be used to determinethe risk of coronary artery disease in Egyptian population living in Suez Canal area.