Why the study?
Does propranolol affect diurnal variability of blood pressure and plasma noradrenaline levels in patients with uncomplicated essential hypertension?
Does propranolol affect diurnal variability of blood pressure and plasma noradrenaline levels in patients with uncomplicated essential hypertension?
Propranolol reduces the pressor range of blood pressure in uncomplicated essential hypertension without altering total diurnal variability or average noradrenaline levels.
Should not change practice for hypertension; leaves open selective effects on pressor range pending randomized confirmation.
The effect of propranolol on diurnal variability of BP and plasma noradrenaline levels was assessed in 15 patients with uncomplicated essential hypertension. While total variability and average noradrenaline level remained unaltered, the pressor range (difference between basal and maximum BP readings) was reduced in most patients. An inverse relationship was observed between changes in pressor range and noradrenaline.
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Leeuw et al. (1977) studied this question.
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