Population
NMRI mice infected with coxsackievirus B3 (experimental model of chronic myocarditis)
Design
Preclinical
Follow-up
Up to 14 days post-infection and into late stage
Authors
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May implicate IL-10 in viral myocarditis pathogenesis; hypothesis-generating in animal models, no clinical translation yet.
Persistently expressed IL-10 in the myocardium following coxsackievirus B3 infection may play a leading role in the pathogenesis of acute and chronic myocarditis by subverting the immune response.
Schmidtke et al. (2000) studied this question.
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