September 1, 1997The Journal of Pathology

Expression of cytokine mRNAs in murine hearts with acute myocarditis caused by coxsackievirus B3

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Population

Murine models of acute viral myocarditis

Design

Preclinical

Authors

YSYoshinori SekoJuntendo University NTNaoyuki TakahashiNihon University HYHideo Yagita∥Brigham Young University

Discussion

Member takes

Implication

Th1 bias in murine viral myocarditis may guide immunomodulation research; leaves open human translation and clinical relevance.

Structured PICO

Population

Murine models of acute viral myocarditis (myocardial cells infected with Coxsackievirus B3 in vivo and in vitro)

Intervention

Coxsackievirus B3 (CVB3) infection

Outcome

Expression of various cytokine mRNAs (IL-1 alpha, IL-1 beta, IL-6, TNF-alpha, TNF-beta, IL-2, IL-3, IL-4, IL-10, IFN-gamma, GM-CSF, and IL-2R) measured by semiquantitative PCRsurrogate

In a murine model of acute viral myocarditis, the early immune response is predominantly mediated by Th1-type cells, as evidenced by stronger expression of Th1-related cytokines compared to Th2-related cytokines.

Cite This Study

Seko et al. (1997) studied this question.

synapsesocial.com/papers/6a73c212d0d1650e4d69f1c5 https://doi.org/10.1002/(sici)1096-9896(199709)183:1<105::aid-path1094>3.0.co;2-e

Topics

Myocarditis

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