Why the study?
Does anti-4-1BBL MAb reduce myocardial inflammation in a murine model of acute viral myocarditis?
Population
Mice with acute myocarditis induced by Coxsackievirus B3 (CVB3) in vivo, and cultured cardiac myocytes
Design
Preclinical
Authors
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Anti-4-1BBL MAb may reduce myocardial inflammation in murine viral myocarditis; hypothesis-generating and requires human validation.
Does anti-4-1BBL MAb reduce myocardial inflammation in a murine model of acute viral myocarditis?
In a murine model of Coxsackievirus B3-induced acute myocarditis, treatment with anti-4-1BBL monoclonal antibody significantly decreased myocardial inflammation, suggesting a potential immunotherapeutic target.
Seko et al. (2001) studied this question.
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