Key Points
- Synthesize available clinical evidence regarding the prevalence, etiology, and treatment outcomes of heart failure across different ethnic minority populations.
- Literature review analyzing epidemiological data, clinical manifestations, and trial findings for heart failure among South Asian, Chinese, African-American, and Aboriginal groups.
- African-Americans and South Asians develop heart failure at younger ages compared to white populations, driven primarily by non-ischemic causes and premature coronary heart disease, respectively.
- Chinese populations frequently manifest heart failure with preserved systolic function secondary to hypertension, while Aboriginal populations experience a disproportionately high burden of atherosclerosis and heart failure.
- Therapeutic responsiveness varies by background, with randomized clinical trial data demonstrating significant efficacy for combined isosorbide dinitrate and hydralazine in Black patients.
Structured PICO
PPopulationEthnic minority groups (South Asians, Chinese, African-Americans, Aboriginal people) in western countries
This review highlights significant ethnic differences in the etiology, prevalence, and treatment response of heart failure, emphasizing the need for more diverse studies.