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November 1, 1978ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)Open Access

Recombinants between herpes simplex virus types 1 and 2: analyses of genome structures and expression of immediate early polypeptides

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Population

17 intertypic recombinants between temperature-sensitive mutants of herpes simplex virus types 1 and 2

Design

Preclinical

Authors

VPV. G. PrestonEast Carolina UniversityADAndrew J. DavisonMRC University of Glasgow Centre for Virus ResearchHMH. S. MarsdenSurrey Satellite Technology (United Kingdom)

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Overview

Maps HSV IE polypeptides to repetitive sequences; extends recombination-based mapping and leaves open functional validation.

Structured PICO

P
Population
17 intertypic recombinants between temperature-sensitive mutants of herpes simplex virus types 1 (HSV-1) and 2 (HSV-2)
I
Intervention
Restriction endonuclease analysis and physical mapping
O
Outcome
Genome composition and physical mapping of immediate early polypeptides

The study maps the immediate early polypeptides of HSV-1 and HSV-2 to specific repetitive sequences in the viral genome using intertypic recombinants.

Cite This Study

Preston et al. (1978) studied this question.

synapsesocial.com/papers/6a73d58df755ad90938de83ehttps://doi.org/10.1128/jvi.28.2.499-517.1978
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sequence arrangement in herpes simplex virus type 1 DNA: identification of terminal fragments in restriction endonuclease digests and evidence for inversions in redundant and unique sequences1976 · 69 citations
  2. 2Control of Protein Synthesis in Herpesvirus-infected Cells: Analysis of the Polypeptides Induced by Wild Type and Sixteen Temperature-sensitive Mutants of HSV strain 171976 · 211 citations
  3. 3Temperature-sensitive Mutants of Herpes Simplex Virus Type 21971 · 109 citations
  4. 4Comparative Analysis of Polypeptides Induced by Type 1 and Type 2 Strains of Herpes Simplex Virus1977 · 17 citations
  5. 5Proteins Specified by Herpes Simplex Virus XI. Identification and Relative Molar Rates of Synthesis of Structural and Nonstructural Herpes Virus Polypeptides in the Infected Cell1973 · 298 citations