January 1, 1983Nucleic Acids ResearchOpen Access

Immediate-early mRNA-2 of herpes simplex viruses types 1 and 2 is unsplced: conserved sequences around the 5′ and 3′ termini correspond to transcription regulatory signals

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Population

Herpes simplex viruses types 1 and 2 (HSV-1, HSV-2) immediate-early (IE) mRNA-2

Design

Preclinical

Authors

Discussion

May guide HSV antiviral targeting; hypothesis-generating and leaves open clinical translation.

Population

Herpes simplex viruses types 1 and 2 (HSV-1, HSV-2) immediate-early (IE) mRNA-2

Intervention

Nuclease S1 and exonuclease VII analyses and DNA sequencing

Outcome

Sequence homology and structural features of the 5' and 3' termini

The study identifies conserved transcription regulatory signals and structural features in the unspliced immediate-early mRNA-2 of HSV-1 and HSV-2.

Whitton et al. (1983) studied this question.

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