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January 1, 1981Nucleic Acids ResearchOpen Access

Reiterated sequences within the intron of an immediate-early gene of herpes simplex virus type 1

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Population

Herpes simplex virus type 1 DNA fragment containing the intron of the immediate-early mRNA-5 (IE mRNA-5) gene

Design

Preclinical

Authors

RWRoger J. WatsonUniversity of BirminghamKUKenichi UmeneFukuoka Women's UniversityLELynn W. EnquistUniversity of Arizona

Discussion

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Implication

No direct clinical implications for HSV-1; extends genomic mapping but leaves open functional roles in latency.

Structured PICO

P
Population
Herpes simplex virus type 1 DNA fragment containing the intron of the immediate-early mRNA-5 (IE mRNA-5) gene
I
Intervention
Nucleotide sequencing, Berk & Sharp nuclease S1 protection analysis, and cloning and sequencing cDNA
O
Outcome
Location and sequence of the intron

The intron of the immediate-early mRNA-5 gene in HSV-1 contains multiple copies of a GC-rich tandem repeat.

Cite This Study

Watson et al. (1981) studied this question.

synapsesocial.com/papers/6a95c8b22ac1158c861bec0dhttps://doi.org/10.1093/nar/9.16.4189
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ribonucleic Acid Synthesis in Cells Infected with Herpes Simplex Virus: Controls of Transcription and of RNA Abundance1972 · 72 citations
  2. 2Orientation of herpes simplex virus type 1 immediate early mRNA's1979 · 77 citations
  3. 3Ovalbumin gene: evidence for a leader sequence in mRNA and DNA sequences at the exon-intron boundaries.1978 · 1,138 citations