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January 1, 1981Journal of VirologyOpen Access

Structures of two spliced herpes simplex virus type 1 immediate-early mRNA's which map at the junctions of the unique and reiterated regions of the virus DNA S component

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Population

Herpes simplex virus type 1 immediate-early (IE) RNAs (IE mRNA-4 and IE mRNA-5) and virus DNA

Design

Preclinical

Authors

RWR J WatsonThe Honourable Society of Lincoln's InnMSM.H.F. SullivanUniversity of North Carolina at Chapel HillGWGeorge F. Vande WoudeVan Andel Institute

Discussion

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Implication

Structural mapping in this animal study does not inform HSV management; leaves open functional roles in latency for targeted research.

Structured PICO

P
Population
Herpes simplex virus type 1 immediate-early (IE) RNAs (IE mRNA-4 and IE mRNA-5) and virus DNA
I
Intervention
Nuclease digestion (S1 and exonuclease VII) and electron microscopy of R-loop structures
O
Outcome
Structure and mapping of IE mRNA-4 and IE mRNA-5surrogate

The study maps the structures of two spliced HSV-1 immediate-early mRNAs, revealing they share common 5'-terminal sequences but have unique 3'-terminal components.

Cite This Study

Watson et al. (1981) studied this question.

synapsesocial.com/papers/6a851a9fabaf849ca59df7a0https://doi.org/10.1128/jvi.37.1.431-444.1981
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1RNA synthesis in cells infected with herpes simplex virus. XII. Sequence complexity and properties of RNA differing in extent of adenylation1976 · 30 citations
  2. 2Separation and characterization of herpes simplex virus type 1 immediate-early mRNA's1979 · 155 citations
  3. 3Hybridization of RNA to double-stranded DNA: formation of R-loops.1976 · 491 citations
  4. 4Characterization of Herpes Simplex Virus Type 1 RNA Present in the Absence of De Novo Protein Synthesis1980 · 101 citations
  5. 5Anatomy of herpes simplex virus DNA VII. alpha-RNA is homologous to noncontiguous sites in both the L and S components of viral DNA1977 · 94 citations