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January 1, 1979Nucleic Acids ResearchOpen Access

Orientation of herpes simplex virus type 1 immediate early mRNA's

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Population

Herpes simplex virus type 1 genome

Design

Preclinical

Authors

JCJ. Barklie ClementsInstitute of Virology of the Slovak Academy of SciencesJMJohn McLauchlanMRC University of Glasgow Centre for Virus ResearchDMDuncan J. McGeochInstitute of Virology of the Slovak Academy of Sciences

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Overview

Proposed HSV-1 IE transcription model; leaves open validation in mammalian infection systems.

Structured PICO

P
Population
Herpes simplex virus type 1 genome
I
Intervention
Mapping cDNA's complementary to the 3'-termini of messages
O
Outcome
Orientation of 4 immediate early (IE) mRNA's

The study maps the orientation of 4 immediate early mRNAs on the HSV-1 genome and proposes a model for their bidirectional transcription from a single promoter region.

Cite This Study

Clements et al. (1979) studied this question.

synapsesocial.com/papers/6a8ff6786e7e048e0989c95fhttps://doi.org/10.1093/nar/7.1.77
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Recombinants between herpes simplex virus types 1 and 2: analyses of genome structures and expression of immediate early polypeptides1978 · 155 citations
  2. 2Direction of Transcription of the Regulatory Gene araC in Escherichia coli B/r1974 · 33 citations
  3. 3Regulation of herpesvirus macromolecular synthesis: sequential transition of polypeptide synthesis requires functional viral polypeptides.1975 · 586 citations
  4. 4Inverted Repetitions in the Chromosome of Herpes Simplex Virus1974 · 357 citations
  5. 5Virus Specified Enzyme Activity and RNA Species in Herpes Simplex Virus Type 1 Transformed Mouse Cells1976 · 16 citations