Population
BHK cells transfected with chimeric plasmids containing the HSV thymidine kinase gene under the control of…
Comparison
Co-transfection with plasmid pMC1 and various… vs Transfection with plasmids lacking the far…
Design
Preclinical
Follow-up
16 to 18 hours
Authors
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Advances dissection of HSV IE gene control; leaves open clinical translation to antiviral strategies.
The far upstream regulatory domain of HSV IE gene 3 is composed of multiple individual units that augment transcription through different mechanisms, including enhancer-like activity and response to the virion polypeptide Vmw65.
Bzik et al. (1986) studied this question.
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