A Novel Cardiac-Restricted Target for Doxorubicin
Population
Neonatal rat cardiomyocytes, rat embryos (7.5 to 14.5 days p.c.), adult rat hearts, and HeLa cells
Design
Preclinical
Authors
Discussion
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Member takes
Implication
CARP may mediate doxorubicin cardiotoxicity in animal models; leaves open relevance to human disease and therapy.
Structured PICO
P
Population
Neonatal rat cardiomyocytes, rat embryos (7.5 to 14.5 days p.c.), adult rat hearts, and HeLa cells
I
Intervention
Doxorubicin exposure and CARP overexpression
O
Outcome
Identification, developmental expression pattern, and transcriptional regulatory function of CARP (cardiac adriamycin-responsive protein)surrogate
Identifies CARP as the first cardiac-restricted transcriptional regulatory protein sensitive to doxorubicin, offering a potential molecular mechanism for its cardiotoxicity.
Cite This Study
Jeyaseelan et al. (1997) studied this question.