Why the study?
Does diabetes mellitus accelerate coronary artery calcium progression and increase myocardial infarction risk, and is statin therapy effective in slowing this progression?
Population
1,310 subjects who underwent sequential electron beam tomography scans at a minimum 1-year interval.
Comparison
Diabetes mellitus and statin therapy vs Nondiabetic subjects and no statin therapy
Design
Cohort
Follow-up
minimum 1-year interval
Authors
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Diabetes accelerates CAC progression on statins; leaves open whether adjunctive therapies reduce events.
Does diabetes mellitus accelerate coronary artery calcium progression and increase myocardial infarction risk, and is statin therapy effective in slowing this progression?
Diabetes mellitus is associated with accelerated coronary atherosclerosis progression compared to nondiabetics, even in the presence of statin therapy.
Raggi et al. (2005) studied this question.