April 14, 2014The Pediatric Infectious Disease Journal

Severe Enterovirus Type 71 Nervous System Infections in Children in the Shanghai Region of China

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Why the study?

Does early intravenous gamma globulin intervention improve survival in children with severe enterovirus 71 infection?

Structured PICO

Does early intravenous gamma globulin intervention improve survival in children with severe enterovirus 71 infection?

Population

220 children aged 1 month to <14 years admitted with confirmed enterovirus 71 (EV71) infection and severe illness (high prolonged fever, very unwell general appearance, and/or neurological findings, with no underlying medical condition) to a tertiary care hospital.

Intervention

Early intravenous gamma globulin (IVIG) intervention

Outcome

Clinical features, morbidity, mortality, and neurological involvementhard clinical

Severe EV71 infection in children carries significant morbidity and mortality, particularly in rural areas, though early IVIG treatment may improve survival.

Discussion

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Implication

Caution against routine early IVIG in severe pediatric EV71; leaves open need for confirmatory RCTs.

Cite This Study

Zhang et al. (2014) studied this question.

synapsesocial.com/papers/6a73dc4bf4f9256fee8de96d https://doi.org/10.1097/inf.0000000000000194

View Full Paper

Ask AI

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Severe Enterovirus Type 71 Nervous System Infections in Children in the Shanghai Region of China

Structured PICO

Discussion

Implication

Cite This Study

Severe Enterovirus Type 71 Nervous System Infections in Children in the Shanghai Region of China

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider