Why the study?
Does night-time dosing of thiazide diuretics improve blood pressure control and cardiac indices compared to morning dosing in Nigerian Africans with hypertension?
Does night-time dosing of thiazide diuretics improve blood pressure control and cardiac indices compared to morning dosing in Nigerian Africans with hypertension?
Night-time dosing of thiazide diuretics may provide superior blood pressure reduction and left ventricular mass regression compared to morning dosing in hypertensive patients.
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May support nocturnal thiazide dosing for BP control and LV regression in African hypertensives; hypothesis-generating and requires RCT confirmation before practice change.
Okeahialam et al. (2012) studied this question.
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