Key result
Four antihypertensive drug classes significantly lowered 24-h mean SBP compared to placebo (P < .05), but their effects varied by time of day, with atenolol causing less reduction than the others.
Why the study?
Do different antihypertensive drug classes have variable effects on ambulatory blood pressure depending on the time of day in older patients with untreated systolic hypertension?
RCT (n=24)
Double-blind
Crossover
Do different antihypertensive drug classes have variable effects on ambulatory blood pressure depending on the time of day in older patients with untreated systolic hypertension?
p-value: p=<.05
Different antihypertensive drug classes have variable effects on blood pressure depending on the time of day, suggesting that antihypertensive therapy may need to be tailored to circadian patterns.
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Supports considering circadian BP patterns when selecting antihypertensive class and timing in older patients; extends RCT evidence on time-specific effects beyond 24-h means.
Trefor Morgan (2003) conducted an RCT in Hypertension (n=24). Atenolol, perindopril, felodipine, or hydrochlorothiazide vs. Placebo was evaluated on 24-h mean SBP (p=<.05). Four antihypertensive drug classes significantly lowered 24-h mean SBP compared to placebo (P < .05), but their effects varied by time of day, with atenolol causing less reduction than the others.
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