Chronotherapy With Valsartan/Hydrochlorothiazide Combination in Essential Hypertension: Improved Sleep-Time Blood Pressure Control With Bedtime Dosing

204 subjects with essential hypertension (95 men/109 women), mean age 49.7 ± 11.1 years. Key inclusion: BP not properly controlled with respect to published ambulatory BP criteria after initial randomization to valsartan monotherapy (160 mg/day) for 12 weeks.

Valsartan/hydrochlorothiazide (160 mg/12.5 mg/day) single-pill formulation administered at bedtime for 12 weeks.

Valsartan/hydrochlorothiazide (160 mg/12.5 mg/day) single-pill formulation administered upon awakening for 12 weeks.

Administration-time-dependent BP-lowering efficacy (48-h BP mean, awake BP mean, asleep BP mean) measured by ambulatory monitoring for 48 h after 12 weeks of therapy.surrogate