Key result
Bed-time administration of valsartan significantly increased the diurnal/nocturnal ratio of systolic (6.6 vs -1.0) and diastolic (5.4 vs -0.3) blood pressure compared to morning dosing (P<0.001).
Why the study?
Does valsartan administered at bed-time improve ambulatory blood pressure profiles compared to morning administration in elderly hypertensive patients?
Population
100 elderly patients with grade 1-2 essential hypertension, mean age 68.2+/-4.9 years, 34 men and 66 women.
Comparison
Valsartan 160 mg/d monotherapy administered at… vs Valsartan 160 mg/d monotherapy administered upon…
Design
RCT, randomly assigned
Follow-up
3 months
Authors
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Bedtime valsartan may improve dipping in elderly hypertensives; leaves open whether timed dosing alters outcomes.
RCT (n=100)
randomly assigned
Does valsartan administered at bed-time improve ambulatory blood pressure profiles compared to morning administration in elderly hypertensive patients?
Absolute Event Rate: 6.6% vs -1%
p-value: p=<0.001
Bed-time administration of valsartan in elderly hypertensive patients improves the nocturnal decline in blood pressure compared to morning dosing, potentially reducing cardiovascular risk.
Hermida et al. (2005) conducted an RCT in grade 1-2 essential hypertension (n=100). Valsartan at bed-time vs. Valsartan upon awakening was evaluated on diurnal/nocturnal ratio of systolic blood pressure (p=<0.001). Bed-time administration of valsartan significantly increased the diurnal/nocturnal ratio of systolic (6.6 vs -1.0) and diastolic (5.4 vs -0.3) blood pressure compared to morning dosing (P<0.001).
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