Key result
Valsartan administered at bedtime significantly increased the diurnal/nocturnal blood pressure ratio (P<0.001) and reduced urinary albumin excretion by 41% compared to administration on awakening.
Why the study?
Does bedtime administration of valsartan improve the diurnal/nocturnal blood pressure ratio and reduce urinary albumin excretion compared to morning administration in patients with grade 1 to 2 essential hypertension?
Population
200 previously untreated nonproteinuric patients with grade 1 to 2 essential hypertension
Comparison
Valsartan 160 mg/d as monotherapy administered… vs Valsartan 160 mg/d as monotherapy administered…
Design
RCT, randomized, open-label, blinded endpoint
Follow-up
3 months
Authors
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Bedtime valsartan may improve dipping status and reduce albuminuria; extends chronotherapy evidence to ARBs in essential hypertension.
RCT (n=200)
Open-label, blinded endpoint
randomized
Does bedtime administration of valsartan improve the diurnal/nocturnal blood pressure ratio and reduce urinary albumin excretion compared to morning administration in patients with grade 1 to 2 essential hypertension?
p-value: p=<0.001
Bedtime administration of valsartan improves the circadian blood pressure profile to a more dipper pattern and reduces urinary albumin excretion in patients with essential hypertension.
Hermida et al. (2005) conducted an RCT in Grade 1 to 2 essential hypertension (n=200). Valsartan at bedtime vs. Valsartan on awakening was evaluated on Diurnal/nocturnal blood pressure ratio and urinary albumin excretion (p=<0.001). Valsartan administered at bedtime significantly increased the diurnal/nocturnal blood pressure ratio (P<0.001) and reduced urinary albumin excretion by 41% compared to administration on awakening.
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