Why the study?
Does valsartan 160 mg/day administered at bedtime improve blood pressure control and diurnal:nocturnal ratio compared to morning administration in non-dipper patients with grade 1-2 essential hypertension?
Population
148 non-dipper patients with grade 1-2 essential hypertension, mean age 53.0+/-12.6 years.
Comparison
Valsartan 160 mg/day monotherapy administered at… vs Valsartan 160 mg/day monotherapy administered on…
Design
RCT, randomly assigned
Follow-up
3 months
Authors
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Supports bedtime dosing to restore dipping without compromising BP reduction; extends chronotherapy evidence in non-dipper hypertension.
Does valsartan 160 mg/day administered at bedtime improve blood pressure control and diurnal:nocturnal ratio compared to morning administration in non-dipper patients with grade 1-2 essential hypertension?
Bedtime administration of valsartan in non-dipper hypertensive patients improves the diurnal:nocturnal blood pressure ratio and increases the rate of reversion to a dipper profile compared to morning administration.
Hermida et al. (2005) studied this question.
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