Key result
Olmesartan administered at bedtime significantly improved nocturnal blood pressure regulation and reduced the prevalence of non-dipping by 48% compared to morning dosing.
Why the study?
Does olmesartan administered at bedtime improve nocturnal blood pressure regulation compared to morning administration in patients with essential hypertension?
Population
123 grade 1 and 2 hypertensive patients, mean age 46.6+/-12.3 years
Comparison
Olmesartan 20 mg/day as monotherapy administered… vs Olmesartan 20 mg/day as monotherapy administered…
Design
RCT, randomly assigned
Follow-up
three months
Authors
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Bedtime olmesartan may be preferred for non-dippers; extends ARB chronotherapy class effect to 24-hour BP profiles.
RCT (n=123)
Does olmesartan administered at bedtime improve nocturnal blood pressure regulation compared to morning administration in patients with essential hypertension?
Bedtime administration of olmesartan improves nocturnal blood pressure dipping compared to morning dosing, suggesting a class effect for ARBs in optimizing 24-hour blood pressure profiles.
Hermida et al. (2009) conducted an RCT in Essential hypertension (grade 1 and 2) (n=123). Olmesartan at bedtime vs. Olmesartan upon awakening was evaluated on 24-hour blood pressure reduction and nocturnal blood pressure mean. Olmesartan administered at bedtime significantly improved nocturnal blood pressure regulation and reduced the prevalence of non-dipping by 48% compared to morning dosing.
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