December 1, 1999Journal of VirologyOpen Access

Ability of Foot-and-Mouth Disease Virus To Form Plaques in Cell Culture Is Associated with Suppression of Alpha/Beta Interferon

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Population

Secondary cells from susceptible animals and mouse embryonic fibroblast cells

Comparison

Infection with foot-and-mouth disease virus… vs Infection with wild-type foot-and-mouth disease…

Design

Preclinical

Authors

JCJarasvech ChinsangaramSiga Technologies (United States)MPMaría E. PicconeNational University of Río Negro MGMarvin J. GrubmanPlum Island Animal Disease Center

Discussion

Member takes

Implication

Supports FMDV attenuation via IFN induction; hypothesis-generating for livestock vaccines pending in vivo studies.

Structured PICO

Population

Secondary cells from susceptible animals (bovine, ovine, and porcine) and mouse embryonic fibroblast cells (with or without IFN-alpha/beta receptors)

Intervention

Infection with foot-and-mouth disease virus genetic variant lacking the leader proteinase coding region (A12-LLV2)

Comparator

Infection with wild-type foot-and-mouth disease virus (A12-IC)

Outcome

Plaque formation, cytopathic effects, virus yields, and IFN-alpha/beta antiviral activitysurrogate

The ability of wild-type foot-and-mouth disease virus to form plaques and spread is associated with its ability to suppress host IFN-alpha/beta expression.

Cite This Study

Chinsangaram et al. (1999) studied this question.

synapsesocial.com/papers/6a73e266f4f9256fee8deb35 https://doi.org/10.1128/jvi.73.12.9891-9898.1999

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