Why the study?
Does aminopeptidase N inhibition augment natriuretic responses to angiotensin III in angiotensin type 1 receptor-blocked rats?
Population
Rats pre-treated with systemic candesartan for 24 hours
Comparison
Cumulative renal interstitial infusion of… vs Angiotensin III alone into 1 kidney, and…
Design
Preclinical
Follow-up
1-hour control followed by 4 doses of 30 minutes each
Authors
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Hypothesis-generating for AT2-mediated natriuresis; human trials required before any therapeutic consideration.
Does aminopeptidase N inhibition augment natriuretic responses to angiotensin III in angiotensin type 1 receptor-blocked rats?
Aminopeptidase N inhibition augments the natriuretic response to angiotensin III in AT1 receptor-blocked rats, suggesting angiotensin III is a major agonist of AT2 receptor-induced natriuresis.
Padia et al. (2006) studied this question.
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