December 28, 2005Hypertension

Renal Angiotensin Type 2 Receptors Mediate Natriuresis Via Angiotensin III in the Angiotensin II Type 1 Receptor–Blocked Rat

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Population

Uninephrectomized rats and rats with both kidneys intact on normal or restricted Na+ intake

Comparison

Renal interstitial administration of candesartan… vs Noninfused kidney as control; absence of…

Design

Preclinical

Authors

SPShetal H. PadiaUniversity of Virginia NHNancy L. HowellUniversity of Virginia HSHelmy M. SiragyGeneral / Preventive / Lipids

Discussion

Member takes

Implication

May promote natriuresis via AT2 receptors in rats; leaves open translation to human hypertension.

Structured PICO

Population

Uninephrectomized rats and rats with both kidneys intact on normal or restricted Na+ intake

Intervention

Renal interstitial administration of candesartan (AT1 blocker) with or without PD-123319 (AT2 blocker); unilateral renal interstitial infusion of Ang II or Ang III with or without systemic candesartan

Comparator

Noninfused kidney as control; absence of PD-123319 or systemic candesartan

Outcome

Na+ excretion (UNaV)surrogate

Intrarenal AT1 receptor blockade induces natriuresis via activation of AT2 receptors by Angiotensin III, but not Angiotensin II.

Cite This Study

Padia et al. (2005) studied this question.

synapsesocial.com/papers/6a789e4c576efb0ddaf83585 https://doi.org/10.1161/01.hyp.0000196950.48596.21

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Renal Angiotensin Type 2 Receptors Mediate Natriuresis Via Angiotensin III in the Angiotensin II Type 1 Receptor–Blocked Rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Renal Angiotensin Type 2 Receptors Mediate Natriuresis Via Angiotensin III in the Angiotensin II Type 1 Receptor–Blocked Rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider