December 25, 2007HypertensionOpen Access

Conversion of Renal Angiotensin II to Angiotensin III Is Critical for AT 2 Receptor–Mediated Natriuresis In Rats

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Population

Sprague-Dawley rats receiving systemic angiotensin type-1 receptor blockade with candesartan for 24 hours

Comparison

Renal interstitial infusion of Ang II + PC-18… vs Renal interstitial infusion of Ang II alone, and…

Design

Preclinical

Authors

SPShetal H. PadiaUniversity of Virginia BKBrandon A. KempUniversity of Virginia Health System NHNancy L. HowellUniversity of Virginia

Discussion

Member takes

Implication

Supports APA-AT2R natriuresis in rats; hypothesis-generating and requires human validation before any clinical consideration.

Structured PICO

Population

Sprague-Dawley rats receiving systemic angiotensin type-1 receptor (AT1R) blockade with candesartan (0.01 mg/kg/min) for 24 hours

Intervention

Renal interstitial (RI) infusion of Ang II + PC-18 (a specific inhibitor of APN), with or without PD-123319 (AT2R antagonist) or EC-33 (selective APA inhibitor)

Comparator

Renal interstitial infusion of Ang II alone, and contralateral kidney receiving vehicle

Outcome

Urinary sodium excretion rate (U(Na)V)surrogate

Conversion of Angiotensin II to Angiotensin III by aminopeptidase A is critical for AT2 receptor-mediated natriuresis in rats.

Cite This Study

Padia et al. (2007) studied this question.

synapsesocial.com/papers/6a717ec2e5469ee92be20059 https://doi.org/10.1161/hypertensionaha.107.103242

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