Why the study?
Are chromosome 4q25 susceptibility variants for atrial fibrillation associated with specific subtypes of ischemic stroke?
Population
4,199 ischemic stroke patients and 3,750 controls derived from 6 studies conducted in Australia, Austria…
Comparison
Presence of chromosome 4q25 variants vs Absence of variants / healthy controls
Design
Case-control
Authors
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Supports 4q25-AF variant link to cardioembolic stroke only; leaves open clinical utility and causal inference.
Are chromosome 4q25 susceptibility variants for atrial fibrillation associated with specific subtypes of ischemic stroke?
The 4q25 susceptibility variant for atrial fibrillation is specifically associated with cardioembolic stroke, but not with noncardiac subtypes of ischemic stroke.
Lemmens et al. (2010) studied this question.
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